Vakgroep Menselijke fysiologie (MFYS)

In certain brain areas, it is possible to generate new neurons. The mechanisms behind this observation are however not well known. Both ‘enriched environment’ and exercise are supposed to increase neurogenesis significantly in the hippocampus. An important factor, influencing neurogenesis, is brain-derived neurotrophic factor (BDNF). In animals, exercise is known to increase neurotransmission and BDNF in different brain areas.

The purpose of this project is to determine the effect of exercise on BDNF in both humans and animals. In humans, we will explore different exercise protocols and their influence on peripheral markers of neurogenesis. Cognitive function will be tested and we will study possible links between the peripheral markers and changes in cognition. Exercise training will consist of both aerobic and strength training in both young subjects and elderly.

In animals, we will study the influence of different exercise protocols on central parameters, and the connection between neurotransmission and neurotrophic factors.